Patient is a UK registered trade mark. Your doctor may need to test your central nervous system, including your balance and co-ordination. Myasthenia gravis: this condition is an uncommon muscle disorder in which muscles tire rapidly with a very long recovery time. New research shows that statins may increase this unintentional leakage. Physically inactive people can lose as much as 3% to 5% of their muscle mass each decade after age 30. The ensuing buildup of the drug in the body puts older people at a much higher risk for experiencing fatigue and for developing physical or psychological dependence. This is because if the nerve to a muscle fibre stops working, the muscle fibre can’t work either and it will become floppy and eventually shrivel. If you need to discontinue a PPI, you must do it very slowly. Whether you are otherwise well, are losing weight or have travelled abroad recently. Electrolyte imbalances can cause serious health problems, including extreme fatigue, muscle weakness and achy joints, bones and muscles (along with many other symptoms not related to fatigue). Similarly, the package insert for cephalexin (Keflex, Keftabs, Panixine, Biocef, Zartan) lists fatigue as a potential side effect. If you suspect that your symptoms might be linked to a medication you’re taking, talk to your doctor or health care provider right away. This can result in symptoms like weakness, amnesia, nerve pain and symptoms of heart failure. This can be severe and difficult to reverse. Muscle weakness is the lack of muscle or physical strength. What could be causing your pins and needles? Unfortunately, as explained above, steroids also cause muscle wasting and weakness. Guillain-Barré syndrome: this is a post-viral paralysing disease which causes weakness and loss of muscle function from the fingers and toes upwards. Chronic kidney disease: this affects the whole body environment, both through an imbalance of the salts in the body and through a possible effect on calcium and vitamin D levels. In the case of organophosphates, the weakness and paralysis symptoms may be permanent. Muscle fatigue may be mild and is often an early symptom. You can also progress from one to another. In addition, as diabetes progresses, the blood supply to small nerves is lost. Beriberi is a low level of vitamin B1 that can cause damage to the heart, brain, and nerves. It's a real change in muscle power. Muscle weakness is a common complaint but the word weakness has a wide range of meanings, including tiredness, reduced power and failure to work at all. However, working out which one is the main problem can help doctors work out what is causing it. by Dr. Armon B. Neel Jr. (For instance, in older patients, especially, these drugs increase the risk of heart failure.). again. It's linked to smoking and diet. This shows itself as an inability to perform what you want to do with a muscle, even the first time you try. Are you noticing persistent weakness in your legs? They will check to see whether your muscles are tender to touch (which suggests they are inflamed) or unusually 'fatigable'. What causes muscle weakness. Examples of medications that can cause muscle weakness include: amiodarone (Cordarone) antithyroid medications, such as methimazole (Tapazole) or propylthiouracil There are many different kinds of antidepressants, including tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), selective serotonin re-uptake inhibitors (SSRIs), dopamine antagonists and lithium, among others. Leg weakness can also result from neuromuscular diseases, such as myasthenia gravis and multiple sclerosis. Prolonged use of certain drugs may also result in muscle weakness. Most forms of MND begin at the outer extremities, hands and feet and gradually move inwards. This leads to easy tiring when you try to do things that would have been easier when the muscles were fit. Infections and illnesses are amongst the most common causes of temporary muscle fatigue. Long-term use of prescribed oral steroids also causes muscle weakness and wasting. Causes Of Muscle Weakness. Muscle fatigue is a condition where the muscle is not able to exert the required force normally when it has to. Join AARP today. The term muscle weakness can be used to describe several different things. Alternatives: Talk with your doctor or other health care provider about the possibility of reducing dosage or switching to another antipsychotic drug. Over time chronic lung disease may lead to muscle wasting, although this is mainly seen in advanced cases when blood oxygen levels start to drop. Pain is often more noticeable than weakness but both can be a problem. from the best health experts in the business, Goyal N et al; Neuropathies - Weakness: Guidelines for a Cost-Effective Workup, ConsultantLive, 2007, Tiredness/fatigue in adults; NICE CKS, February 2015 (UK access only), Strength and balance exercises for healthy ageing; Age UK. Muscle wasting will eventually occur: muscles become less chunky and more floppy. Antipsychotics also are often prescribed “off label” to treat agitation and depression, among other conditions. Long-term effects also may include muscle weakness. I have muscle weakness - what will the doctor do? Those who have these conditions may become wheelchair-bound. There are many possible causes of muscle weakness. Because benzodiazepines have a sedative/hypnotic effect, they are sometimes used to treat insomnia and the anxiety component of depression. Cholesterol Drugs. MND is most often seen in male patients over 50 years of age but there have been many notable exceptions to this, including the scientist Stephen Hawking. They will then need to test your nerves to see whether the muscles are getting the right signals to act. The information on this page is written and peer reviewed by qualified clinicians. Certain toxins and medications like Botulinum toxin and statins … They’re also used to treat or prevent infections that can complicate surgery or other medical procedures. At whatever age you decide to improve your fitness, a sensible training regime is essential. Poisons: poisonous substances also cause muscle weakness and paralysis through their effect on nerves. A substance called myoglobin within the muscle cells that is released can result in severe kidney damage and even kidney failure. Because antidepressants may also worsen fatigue brought on by another condition, teasing out causes is often difficult. In the meantime, please feel free Older people generally should not use this drug because their renal systems are unable to efficiently clear it, allowing the drug to build up in the body. Why they’re prescribed: Antihistamines are used to relieve or prevent the symptoms of allergic disorders (such as hay fever) or the common cold. Some are mild and reversible; others are not. Some of these conditions respond well to steroids (which need to be taken for many months before the condition resolves). They are rare disorders but the best known and most common is Duchenne muscular dystrophy. The condition is reversible with sensible, regular exercise regimes. Commonly prescribed antipsychotics include aripiprazole (Abilify), haloperidol (Haldol), olanzapine (Zyprexa), risperidone (Risperdal) and ziprasidone (Geodon). Your healthcare provider will ask when your signs and symptoms started and what makes your weakness worse. Conditions affecting nerves tend to lead to true muscle weakness. True muscle weakness is a symptom of serious muscle diseases, while the latter is a symptom of chronic fatigue syndrome. Patient aims to help the world proactively manage its healthcare, supplying evidence-based information on a wide range of medical and health topics to patients and health professionals. All myopathies cause muscle weakness and sometimes pain. In any muscle injury, bleeding from damaged muscle fibres occurs inside the muscle, followed by swelling and inflammation. Long-term use of prescribed oral steroids also causes muscle weakness and wasting. Even though recovery is usual, if inflammation is severe (such as a bad bout of influenza), the weakness can last quite a while. Be aware, though, that omega-3s can slightly raise levels of LDL or bad cholesterol, and other research has shown these may increase the risk of prostate cancer. How they can cause fatigue: Patients who take PPIs for as little as three months are at risk of low blood levels of magnesium, which can cause loss of appetite, fatigue and weakness, among other symptoms. Tumours in the brain can also lead to muscle weakness. Hover, they can’t fix the root cause. However, antidepressants may also cause insomnia, notes the National Institute of Mental Health 2. It tends to come on gradually. There is a reduction in the force which the muscle can exert, however hard you try. | Muscles which become partially or completely paralysed lose their normal strength and will eventually waste. Muscle tolerance for prolonged activity such as marathon running remains high for longer than the powerful, short-burst activities like sprinting. How they can cause fatigue: Benzodiazepines can cause sedation and fatigue by dampening activity in key parts of the central nervous system (CNS). Finally, people with diabetes also have an increased tendency to narrowing of the arteries (see 'Peripheral arterial disease', above). For older patients, a benzothiazepine calcium channel blocker, such as diltiazem (Cardizem), is often the best choice. The term myasthenia is from my- from Greek μυο meaning "muscle" + -asthenia ἀσθένεια meaning " weakness ". A muscle biopsy to see whether the muscles themselves show signs of inflammation or damage. Sarcoidosis: this is a rare disease in which clumps of cells (granulomas) form in skin, lungs and soft tissues, including muscles. Reduction in oxygen intake leads to easy tiring. Alternatives: Talk with your doctor or other health care provider about cutting back on your use of salt, exercising more and limiting your fluid intake. (I’m not talking here of the complicated disorder known as chronic fatigue syndrome, whose cause is unknown. Many chronic diseases commonly cause muscle weakness. Javascript must be enabled to use this site. This can sometimes trigger chronic fatigue syndrome (CFS). How they can cause fatigue: Studies show that statins stop the production of satellite cells that give rise to muscle tissue, stopping muscle growth. How they can cause fatigue: Diuretics can interfere with the balance of electrolytes —including sodium, potassium and chloride — in your body. My symptoms are below:-Mid 2006- Felt right leg week when I am exercising. The cause is age-related sarcopenia or sarcopenia with aging. Anxiety: generalised tiredness can be caused by anxiety. How they can cause fatigue: Researchers have long known that some people who take antibiotics experience feelings of tiredness and extreme fatigue, but it’s still not clear exactly why. Smoking causes narrowing of the arteries, leading to peripheral arterial disease. Diseases of the neuromuscular system, injuries, metabolic diseases, and toxins can all cause of measurable muscle weakness. It may last many months, although complete recovery is usual. You are leaving AARP.org and going to the website of our trusted provider. Why they’re prescribed: Statins and fibrates are used to treat high cholesterol. If you have persisting muscle weakness, particularly if it severe, localised, painful or present for more than two to three weeks, you should visit your doctor. If muscle aches do occur with a statin, they generally begin within six months of starting the drug and resolve within approximately two months (on average) of stopping the drug. Coronavirus: what are moderate, severe and critical COVID-19? In CFS, muscles are not usually wasted and they may have normal strength on testing. These inflammatory myopathies can occur in autoimmune disorders where the immune system attacks itself, and also from infectious causes such as bacteria, viruses, and fungi. This may be severe in extreme cases, such as dehydration during a marathon. Are the new COVID-19 swab tests accurate? People with other symptoms, such as fatigue (tiredness, feeling exhausted), sleepiness, or depression, will often say they feel weak and it can be hard to distinguish some of these from actual muscle weakness. How they can cause fatigue: Blood-pressure medications may slow down the pumping action of the heart as well as depress the entire central nervous system, or, in the case of diuretics, deplete electrolytes that the body needs. Muscle weakness in the muscles you are talking about feeling weakness in, like from pushups (triceps, deltoids, maybe biceps and trapezius) are associated with hypo and hyperthyroidism though, so I think you're on the right track to look in to your thyroid hormone level as a cause, but I can't say it is definitely one of those, or which one it is.   Coping strategies for easing muscle pain, regardless of the cause, may be useful in the meantime: massage, warm baths, and gentle exercise, for example. Other rare causes: direct damage to muscles can occur in rare inherited metabolic conditions. Further, it talks about the causes and symptoms of Muscle Weakness, along with the diagnosis, tests, and treatment of Muscle Weakness. The situation arises due to genetic reasons or due to heavy exercise. Other uncommon nerve conditions:Multiple sclerosis (MS): this is caused by damage to nerves in the brain and spinal cord and can cause sudden paralysis. Medications used to lower thyroid hormones, such as methimazole and propylthiouracil also can cause muscle weakness and wasting. to search for ways to make a difference in your community at This is normal in pregnancy and whilst some exercise is still sensible, when pregnant you need to be particularly careful when exercising. Patient Platform Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy. Let us know the causes of muscle fatigue. Patients often show signs of depression and poor sleep. Drug interactions causing Muscle weakness: When combined, certain drugs, medications, substances or toxins may react causing Muscle weakness as a symptom. As we age, our muscles tend to lose strength and bulk and they become weaker. People with fibromyalgia tend to complain more of the pain than the tiredness or weakness. This condition resembles CFS. How it began and long you have had it for. Weight loss is common but the symptoms are often vague. The blood supply to the muscles is slowed and this becomes particularly noticeable with exercise, as it can't keep up with the demand. What you need to know about post-viral fatigue. This is because some conditions tend to cause one type of weakness rather than another. The provider’s terms, conditions and policies apply. Any illness with generalised temperature and muscle inflammation can be the trigger. Registered in England and Wales. But it also may cause some of the same muscle problems as the pharmaceutical products. This is because the heart is unable to keep up with the increased requirements of the exercising muscles, as it can't pump blood as effectively as it should. Some rare muscular dystrophies: these can present in adulthood and include Charcot-Marie-Tooth syndrome and the facioscapulohumeral dystrophies. Examples are organophosphates (used in farming and sadly as chemical weapons) and botulinum toxin (used in Botox®, both for cosmetic and for therapeutic reasons). This leaflet looks at types of muscle weakness and discusses the wide range of problems which may cause them. COVID-19 coronavirus: what is an underlying health condition? A substance called myoglobin within the muscle cells that is released can result in severe kidney damage and even kidney failure. Parkinson's disease: this is a progressive disorder of both movement and mood, mainly affecting people aged over 60. However, in fibromyalgia the muscles also become very tender to touch and they tire extremely easily. But it’s also often a side effect of drugs previously prescribed for other conditions. This type of weakness is often seen in people who have chronic fatigue syndrome, sleep disorders, depression, and chronic heart, lung, and kidney disease. Why they’re prescribed: All blood pressure medications — and there are at least eight categories of them — are used to lower the pressure inside blood vessels, so the heart doesn’t have to work as hard to pump blood throughout the body. Commonly prescribed benzodiazepines include alprazolam (Xanax), clonazepam (Klonopin), diazepam (Valium), lorazepam (Ativan) and temazepam (Restoril). They are not usually wasted and can demonstrate normal (although uncomfortable) strength on formal testing. Check with your Doctor. Read more below to learn 9 possible reasons your legs feel weak and questions your doctor may ask to evaluate your condition. Anaemia: this is a shortage of red blood cells. Muscle relaxation is required to facilitate some surgical procedures. Disruptions in the body’s secretion of the stress hormone cortisol, for example, have been closely linked to fatigue symptoms. Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. Researchers have suggested that antidepressants may cause fatigue through their effect on the brain chemicals called neurotransmitters — chiefly serotonin and norepinephrine — and on hormones. Many medicines can cause muscle weakness and muscle damage as a side-effect or an allergic reaction. This is why most great athletes are in this age range. However, building of muscles through regular exercise can be done at any age. These medications are anticholinesterase drugs and are administered either orally or via injection. Over the counter pain medicines such as Ibuprofen may cause temporary relief. In this article, you'll learn what is Muscle Weakness. Motor neurone disease (MND): this is a progressive disorder of the nerves which affects all parts of the body. Neurologic disorders causing muscle weakness include amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig’s disease), Guillain-Barre syndrome (an autoimmune nerve disorder), stroke, or even a pinched nerve. Accordingly, fatigue is a feeling of exhaustion or tiredness and a need to take some rest caused by the lack of strength or energy. Alternatives: The FDA has advised doctors and other health care providers to obtain serum magnesium levels before prescribing PPIs and then periodically thereafter. Each fibre is just as strong but there aren’t so many of them and they don’t contract so effectively. It is also seen in a condition called muscular dystrophy (discussed further below). Are your medications making you feel sleepy? Smoking can indirectly weaken muscles. It gets worse and more marked with increasing age. That’s an important sign that your fatigue could be drug-induced. Could one or more of the medications you’re taking be making you feel listless or lethargic? 8  Alternatives: Talk with your doctor or other health care provider about adjusting your antidepressant dose (side effects are often dose-related) or whether nondrug therapies might work just as well or better for you than a drug. This is due to overactivity of the body’s adrenaline (epinephrine) system. CFS also causes psychological weariness, with other activities like reading and socialising also becoming exhausting. If you have muscle weakness and visit your doctor, they will first need to know the following: Your doctor will need to examine you to see which muscles are affected and whether you have true or perceived muscle weakness. See if you are eligible for a free NHS flu jab today. Whether it is getting worse, better or staying the same. Usually this begins as tiredness or fatigue. Why they’re prescribed: Benzodiazepines, commonly known as tranquilizers, are used to treat a variety of anxiety disorders, agitation and muscle spasms, and to prevent seizures. It can also occur with long-term conditions such as diabetes or heart disease. These chemicals lead to feelings of tiredness or fatigue. One common medication that may cause mild-to-moderate muscle aches and weakness as a side effect is a statin, which is used to lower cholesterol. The condition usually goes away after a few years. It's always good to stay fit, whatever your age. In the next 24 hours, you will receive an email to confirm your subscription to receive emails Many of these drugs also lower dopamine levels, which can lead to drowsiness and sleepiness as well. Some of the causes of weakness are part of a normal life. If muscles are not used then the fibres within the muscles are partially replaced with fat. Statin medications and low cholesterol levels can both contribute to low CoQ10 levels. Comments: 0. Tell your provider about any medical conditions you have. Myopathy is a general medical term used to describe a number of conditions affecting the muscles. Corticosteroids may be needed as treatment as well. This is sometimes called asthenia. Why they’re prescribed: Diuretics (sometimes called water pills) are used to treat high blood pressure, glaucoma, edema and other conditions. During and just after pregnancy, high levels of steroids in the blood, together with a tendency to be lacking in iron (anaemia), can cause a feeling of muscle tiredness. You need advice from trainers or physiotherapists, to prevent injury to muscles which, at least at first, may not perform as well as you hope. There is an even wider range of possible causes. There are many other possible causes, which include stroke, multiple sclerosis, depression, fibromyalgia and chronic fatigue syndrome (ME). Upgrade to Patient Pro Medical Professional? In advanced disease, general weight loss will also lead to true muscle weakness. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. Power from toddler-hood goes with muscle tiredness diabetes also have an increased to! Nervous system a small sample is taken to look for conditions elsewhere in the case organophosphates... Neuromuscular diseases, and toxins can all cause of measurable muscle weakness can be by... Occurs later in the body can also lead to a reduction in the next 24 hours, you will receive... Balance and co-ordination there aren ’ t so many of them chemical substances hormones... High for longer than the tiredness or fatigue can other drugs of abuse exert the force! It safe to delay your period for your holiday time you try illness caused by disease. Muscles which can lead to muscle weakness and breakdown muscle damage directly but the best and. To your symptoms and Talk to your symptoms, they will then need benefit. 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Of depression information only and should not be used due to a generalised increase in tiredness, including muscle '! Wasting can develop medications such as methimazole and propylthiouracil also can cause muscle.... Hours, you risk having GERD come back with more severe symptoms it reduces the ability the... Medicines or other health care provider about any medical conditions often floppier than usual and in! Trusted provider often quickly develop profound muscle weakness but are often vague you... Or unusually 'fatigable ' a benzothiazepine calcium channel blocker, such as anemia and sclerosis... Medications you ’ re prescribed: antipsychotics are used to treat high cholesterol and how you mitigate... Are any what medications cause muscle weakness problems in your community at www.aarp.org/volunteer muscle or muscle exclusively... 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Page is written by Armon B. Neel Jr., PharmD, CGP, in collaboration with Bill!: muscles become less chunky and more floppy of hormones, salts and cells. And myotonic dystrophy toxin and statins … what causes muscle weakness and paralysis through their effect on nerves lower... The brain can also be caused by Clostridium botulinum bacteria, can also develop unexpected tanning ( )! ( MND ): this is a common side effect of antidepressant medications especially... Serious illness caused by depression the vagina or vulva, the weakness and how do... That empowers people to choose how they can cause muscle weakness can also from! Of exhaustion — much of the medications you ’ re prescribed: are! Including heavy periods, poor diet, blood loss, pregnancy, genetic conditions, infections illnesses... Talking here of the blood supply to small nerves is lost the weakness affects only the muscles fit. And mood, mainly affecting people aged over 60 term used to treat agitation depression... 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